Early Marker Identified for Pancreatic Cancer
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Scientists have identified a new biomarker for pancreatic cancer. The early marker helps researchers move one step closer in creating therapeutic treatments for the potentially deadly disease.
Pancreatic cancer can grow without symptoms and a tumor is often in advanced stages of growth by the time the tumor is found. According to the National Cancer Institute, Pancreatic cancer is the 4th leading cause of cancer-related death in the United States. According to journal Cancer Research, newly diagnosed patients have a survival rate of less than a year.
A kinase [enzyme] called PEAK1 is turned on very early in pancreatic cancer. This protein was clearly detected in biopsies of malignant tumors from human patients - at the gene and the protein levels - as well as in mouse models.
A kinase is an enzyme that helps to regulate cell function. A biomarker is a general term for a substance in the body that is used to indicate some sort of biological state. Researchers said the specific biomarker they identified acts as an on and off switch for cellular function. It is needed for the cancer to grow and spread. IT is critical to understand the importance in understanding how pancreatic cancer develops if we are ever going to develop effective treatments for this deadly disease
The data is preliminary and were observed under tightly controlled experimental conditions, so the extent to which the biomarkers will be relevant to patients has yet to be determined. Biomarkers can have many functions, such as screening high risk patients, aid in diagnosis, offer information as to how aggressive the disease is and help establish a point of attack in development new treatments.
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